Review
Low Density Lipoprotein Receptor-Related Protein
Author(s): Nicklaus Leister*
The protein known as cluster of differentiation 91 (CD91), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER), or low density lipoprotein receptor-related protein 1 (LRP1), forms a receptor in the plasma membrane of cells that participate in receptor-mediated endocytosis. The LRP1 gene in humans encodes the LRP1 protein. As a crucial signalling protein, LRP1 is also involved in a number of biological functions, including lipoprotein metabolism and cell motility, as well as disorders including cancer, atherosclerosis, and neurodegenerative illnesses (Therese et al., 2019). LRP1, a member of the LDLR family, is widely expressed in a variety of tissues, although it is most prevalent in neurons, hepatocytes, and vascular smooth muscle cells (SMCs). LRP1 is involved in numerous cellular and biological processes, including lipid and lipoprotein metabolism.. View More»
DOI:
10.14303/2250-9941.2023.63