Aptamers: Future pharmaceutical drugs | 16846
International Research Journals
Reach Us +44 330 818 7254

International Research Journal of Pharmacy and Pharmacology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Aptamers: Future pharmaceutical drugs


Cristina Romero-López, Rocío Guadix-Arroyo and Alfredo Berzal-Herranz

In vitro selection strategies are powerful tools for the identification of nucleic acids with unsuspected activities. Their successful application during last two decades has positioned these technologies among those most promising for the development of therapeutic and diagnostic agents. Aptamers are DNA or RNA molecules with special conformational features, able to efficiently bind to a target molecule. They are obtained by SELEX, a particular in vitroselection strategy, and have found utility during last years as a novel class of pharmaceuticals compounds. This review summarizes the progress made in the use of aptamers as therapeutic agents, paying special attention to those examples that have concluded in pharmacological formulations currently included in preclinical and clinical trials.

Share this article