International Research Journals
Reach Us +44 330 818 7254

International Research Journal of Engineering Science, Technology and Innovation

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Owen Park

Department of Mechanical Engineering, Somalia


  • Mini Review   
    Pre-Osteoblast Differentiation and Proliferation Following Combined Mechanical Stimulation
    Author(s): Owen Park*

    A bioreactor system that can simultaneously stimulate cells with cyclic strain and ultrasound, both of which are known to effectively stimulate the regeneration of bone tissue, was developed for this study. Due to their osteoblast-like characteristics, MC3T3-E1 pre-osteoblasts were chosen for use in bone tissue engineering. PolyL-lactic acid and polycaprolactone were used in the salt leaching process to create three-dimensional scaffolds. The bioreactor used ultrasound and cyclic strain to stimulate the cells. For ultrasound, the bioreactor was set to 1.0 MHz and 30 mW/cm2 at 1.0 Hz and 10% strain for cyclic strain. A control group and three experimental groups—ultrasound, cyclic strain, and combined stimulation—were examined. For 20 minutes each day, each group was stimulated. When measured using the cell counting kit-8, mechanical stimuli had no significant effect on th.. View More»
    DOI: 10.14303/2315-5663.2023.92

    Abstract HTML PDF