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International Research Journal of Pharmacy and Pharmacology

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Jeremy Sprague

Department of pharmacy, Bowling Green State University, USA


  • Review Article   
    A Review on the pharmacokinetics action of benzodiazepine
    Author(s): Jeremy Sprague*

    Designer benzodiazepines, including flualprazolam and flubromazolam, are clandestinely delivered to circumvent federal controls. Although flualprazolam and flubromazolam are fundamentally comparative to alprazolam, they do not have an endorsed medical sign. Flualprazolam differs from alprazolam by the expansion of a single fluorine particle. While, flubromazolam varies by the addition of a single fluorine particle and substitution of a bromine for a chlorine molecule. The pharmacokinetics of these designer compounds has not been extensively evaluated. Within the show consider, we evaluated flualprazolam and flubromazolam in a rat show and compared the pharmacokinetics of both compounds to alprazolam. Twelve male, Sprague-Dawley rats were given a 2 mg/kg subcutaneous dose of alprazolam, flualprazolam and flubromazolam and plasma pharmacokinetic parameters were assessed. Both compounds .. View More»
    DOI: 10.14303/2251-0176.2023.68

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