International Research Journals

Asif Hanif

Department Of Health and Clinical Research, Pakistan


  • Mini Review   
    Membrane Properties of Human Induced Pluripotent Stem Cell-Derived Cultured Red Blood Cells
    Author(s): Asif Hanif*

    Cultured red blood cells from human induced pluripotent stem cells (cRBC_iPSCs) are a promising source for future concepts in transfusion medicine. Before cRBC_iPSCs will have entrance into clinical or laboratory use, their functional properties and safety have to be carefully validated. Due to the limitations of established culture systems, such studies are still missing. Improved erythropoiesis in a recently established culture system, closer simulating the physiological niche, enabled us to conduct functional characterization of enucleated cRBC_iPSCs with a focus on membrane properties. Morphology and maturation stage of cRBC_iPSCs were closer to native reticulocytes (nRETs) than to native red blood cells (nRBCs). Whereas osmotic resistance of cRBC_iPSCs was similar to nRETs, their deformability was slightly impaired. Since no obvious alterations in membrane morphology, lipid compo.. View More»
    DOI: 10.14303/irjbcs.2022.17

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