Study on effect of environmental and occupational pesticide | 97773
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Journal of Research in Environmental Science and Toxicology

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Study on effect of environmental and occupational pesticide exposure on marker enzymes of malignancies in cancer patients


Anupama Ojha*, Shashank Shekhar, Poonam Gupta, Harikeshbahadur Singh, Sonali Jaiswal and Sarad Kumar Mishra

Cancer is one of the top leading causes of death and increasing globally on daily basis. Environmental exposure to pesticides causes disposition to various types of cancer in humans. The prime objective of the current research was to analyze the synergistic effect of pesticides in carcinogenesis through measuring the oxidative stress marker enzymes in serum/plasma of the cancer patients as compared to the control sample. We have found a significant decrease in the level of monooxygenase, Glutathione S-transferase, acetylcholine esterase and, total protein along with a significant increase in β-glucuronidase activity in serum sample of cancer patients as compared to control. However we have not found synergistic role of pesticide in carcinogenesis. To validate the above results further studies on large sample size are required.

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