In vitro antioxidant capacity and antiproliferative effects of different parts and extractions from Ajuga bracteosa on HepG2 cell line

Abstract

Jung-Jui Chao, Diana Lo, Nitinant Panboon, Ming-Chang Wu

The aim of this study was to investigate phenolic content, antioxidant activity and antiproliferative of Ajuga bracteosa extracts. These results revealed that A. bracteosa flower in water extract contained high amount of phenolic, flavonoids and tannin at 34.23 µg/ml (GAE), 14.23 µg/ml (QE) and 1.606 µg/ml (TE), respectively. Compared to positive control, A. bracteosa showed highest result in DPPH radical scavenging activity while lowest result in TEAC assays (ABTS radical scavenging activity) and reducing power. Leaf in water extract ofA. bracteosa presented the highest activity in DPPH radical scavenging activity, while water, ethanol and methanol extracts of A. bracteosa flower showed highest antioxidant activity in TEAC assay compared to other parts. A. bracteosa from water extraction and flower part revealed highest activity in antiproliferative effect. From correlation analysis, radical scavenging activity of A. bracteosa may be influenced by all phenolic content, while antiproliferative effect may due to flavonoid content. In conclusion, water extract from flower A. bracteosa might be used as a potential source of natural antioxidants and antitumor agents.

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