Histone Deacetylase Inhibition Restores Expression of Hypoxi | 71964
International Research Journals

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Histone Deacetylase Inhibition Restores Expression of Hypoxia-inducible Protein NDRG1 in Pancreatic Cancer


Céline Tiffon

Pancreatic ductal adenocarcinoma, the most common subtype of human pancreatic cancer, affects both men and women and is highly aggressive, with a five-year survival rate of only about 5%. N-myc downstream-regulated gene-1 (NDRG1) is a hypoxia-inducible and differentiation-related protein and candidate biomarker in pancreatic cancer. As NDRG1 expression is lost in high-grade tumors, the effects of the differentiating histone deacetylase inhibitor trichostatin A (TSA) were examined in human pancreatic cancer cell lines representing different tumor grades. Panc-1 (poorly differentiated) and Capan-1 (moderately- to well-differentiated) cells were treated with TSA

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