Uday V Kiran*, Muniya M Naik, Veera Nagendra D Kumar, Rama M Mohan, Jayasankar A, Subramanyam P, Venkata Viswa P Prasad and Venkata Mohan P Reddy
A great source of different polyphenols with powerful antioxidant and disease-prevention qualities is grape seed extract (VGSE), which comes from the vine species Vitis vinifera. There is a lack of research about the health advantages of VGSE on DNA damage, protein damage, labile iron activity, and enzyme inhibitory effects, despite the fact that VGSE has a wide range of biological activities that have the potential to improve human health. By exerting anti-oxidative, anti-inflammatory, anti-acetylcholinesterase, and anti-amyloidogenic effects, grape-derived extracts are natural sources of polyphenols that may promote healthy brain ageing. The acetyl cholinesterase enzyme, which is discussed in this article, is involved in the cessation of cholinergic transmission, and it has been demonstrated that Alzheimer disease increases this enzyme's activity. We focus on the processes behind the neuromodulating properties of polyphenolic extracts and chemicals obtained from grapes, particularly resveratrol, grape seed extract, and extracts from grape leaves. However, additional study is needed to determine the most potent medicinal extracts and chemicals, as well as their brain bioavailability.
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