International Research Journals

International Research Journal of Biochemistry and Bioinformatics

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Himawari Nohara

Laboratory of Cell Regulation, Tokyo, Japan


  • Review   
    Gene Expression Control in Hypoxic Conditions Involved in Wound Healing
    Author(s): Himawari Nohara*

    Haemostasis, inflammation, proliferation, and remodelling are some of the phases that make up the complex process of wound healing, which is controlled by numerous signals. The main cell types involved in wound healing are keratinocytes, endothelial cells, macrophages, and fibroblasts. Since cells detect hypoxic conditions and alter their gene expression in response, hypoxia plays a crucial role in this process. This investigation examined the in vitro expression of 77 genes in human keratinocytes (HaCaT), microvascular endothelial cells (HMEC-1), differentiated macrophages (THP-1), and dermal fibroblasts that are involved in angiogenesis, metabolism, cell development, proliferation, and death (HDF). The results showed that hypoxia-induced gene expression profiles were cell-type specific. Most of the genes regulated by hypoxia in HMEC-1 and differentiated THP-1 encode angiogenesis-rel.. View More»
    DOI: 10.14303/2250-9941.2022.45

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