International Research Journals

International Research Journal of Biochemistry and Bioinformatics

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Hamid Kaif

Department of Medicinal Chemistry, Washington, USA


  • Mini Review   
    Usage of Hydrogen/Deuterium Exchange Mass Spectrometry to Bridge Protein Structure, Dynamics, and Function
    Author(s): Hamid Kaif*

    The analysis of the structural characteristics and dynamic properties of proteins is being done using a technology called hydrogen/deuterium exchange mass spectrometry, or HDX-MS. It might stand alone or work in conjunction with structural biology techniques such as cryo-electron microscopy (EM). Both small protein complexes and big protein aggregates may be studied using HDX-MS. Due to recent methodological developments and expanding equipment availability, HDX-MS is increasingly being used on a regular basis for various applications. Conformation and ligand interaction analyses by HDX-MS are already practically standard procedures when working with samples of low to medium complexity and sizes of less than 150 kDa. The quick development of the computational (software) backdrop, which makes it easier to analyse the data from the experiments, is another strong argument in favour of th.. View More»
    DOI: 10.14303/2250-9941.2022.44

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