Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active Lisomer of ofloxacin. It is an antibiotic that is active against both Gram-positive and Gram-negative bacteria and is used to treat a number of bacterial infections including acute bacterial sinusitis, pneumonia, H-pylori (in combination with other medication), urinary tract infections, chronic prostatitis, and some types of gastroenteritis. Quality control is the set of measures and procedures to follow in order to ensure that the quality of a product is maintained and improved against a set of benchmarks and that any errors encountered are either eliminated or reduced. Invitro profile also helps us to get an idea of how drug will behave in-vivo. Different brands of Levofloxacin tablets are known to show different Pharmacokinetic parameters and release profiles. A study was planned because of lack of data about Quality Control tests on Levofloxacin tablets available in Oman. The objectives of our study were to carry out dissolution rate studies on all the available brands and to find out the best brand in terms of the Quality Control test parameters and release of the drug from the formulations.
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