Targeted Knockdown of IQGAP1 Fully Inhibits The Progression | 72893
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International Research Journal of Pharmacy and Pharmacology

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Targeted Knockdown of IQGAP1 Fully Inhibits The Progression of Colorectal Carcinoma Cell In Vitro by Modulation of Ras and TRAILs Genes Expression


Khairy M A Zoheir

For many years, the medical setting up has called the chronic or life- threatening diseases incurable But now, The gene therapy compromises hope for those looking for release from hundreds of different diseases. The objective of this application was to determine the outcome of inhibiting IQGAP1 and consequently Ras family genes and TRAIL-induced apoptosis in colorectal carcinoma cells (HCT166) and to delineated the mechanism of such modulation. We investigated the impact of IQGAP1 silencing on the interactions of IQGAPs and RAS with several apoptotic, pre-apoptotic and anti- apoptotic genes, including caspase-3 (CASP3), BCL2-associated X protein (BAX), B-cell leukemia/lymphoma 2 (BCL2), TRAIL1, DR4, DR5, CXCR1, CXCR2, Dcoy receptor 1, Dcoy receptor 2, and Cxcr3 and programmed cell death 5 (Pdcd5),. Additionally, we investigated the effects of the interactions of these genes on cell viability, proliferation, apoptosis, and invasive capacity.

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