Khairy M A Zoheir
For many years, the medical setting up has called the chronic or life- threatening diseases incurable But now, The gene therapy compromises hope for those looking for release from hundreds of different diseases. The objective of this application was to determine the outcome of inhibiting IQGAP1 and consequently Ras family genes and TRAIL-induced apoptosis in colorectal carcinoma cells (HCT166) and to delineated the mechanism of such modulation. We investigated the impact of IQGAP1 silencing on the interactions of IQGAPs and RAS with several apoptotic, pre-apoptotic and anti- apoptotic genes, including caspase-3 (CASP3), BCL2-associated X protein (BAX), B-cell leukemia/lymphoma 2 (BCL2), TRAIL1, DR4, DR5, CXCR1, CXCR2, Dcoy receptor 1, Dcoy receptor 2, and Cxcr3 and programmed cell death 5 (Pdcd5),. Additionally, we investigated the effects of the interactions of these genes on cell viability, proliferation, apoptosis, and invasive capacity.
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