*Shahenda Mahgoub1, Zeinab Hassan1, Atef Bassyouni2 and Mahmoud Youns
Heat shock protein 27 (HSP27) has been involved in different kidney diseases playing protective as well as counter-protective roles. Stressful conditions that include oxidative stress as diabetes and chronic kidney disease promote cells to over express HSP27. In the present study, investigation of serum Hsp27 levels in type 2 diabetic Egyptians with traditional risk factors for diabetic nephropathy (DN), a microvascular complication in type 2 diabetes mellitus, as well as in diabetics with evident diabetic nephropathy was performed. Our study included three diabetic groups: diabetic control subjects (DC), diabetic group with one or more of the traditional risk factors for diabetic nephropathy (DR): Hypertension and /or dyslipidemia, and evident diabetic nephropathy group (DN), which was further sub-grouped into three DN stages according to the decrease in the estimated glomeular filtration rate. Serum Hsp27 levels were significantly higher in patients with traditional risk factors for DN and with evident DN than in diabetic control subjects (p<0.01). Moreover, serum HSP27 showed increased area under the curve with increasing risk factors for DN. Likewise, serum Hsp27 levels showed higher sensitivity and area under the curve over creatinine and microalbuminuria. In conclusion, our results showed that serum HSP27 may be used as an early marker for diagnosis of diabetic nephropathy as serum Hsp27 levels appear to be associated with the risk for DN as well as with manifest DN.
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