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International Research Journal of Pharmacy and Pharmacology

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Pharmacokinetics: The Engine Behind Drug Development and Optimization

Abstract

Anita Verma

Pharmacokinetics (PK) examines the absorption,
distribution, metabolism, and excretion (ADME) of drugs
within the human body. It provides essential insights for
designing dosage regimens, predicting drug interactions,
and ensuring patient safety. Modern drug development
integrates PK studies early in the research process to
optimize bioavailability, minimize toxicity, and improve
therapeutic efficacy. Understanding PK parameters like
half-life, clearance, and volume of distribution is critical for
both preclinical and clinical stages. This article outlines
the role of pharmacokinetics in drug development, its
analytical methods, and its contribution to personalized
medicine.

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