Pharmacodynamics model of the effect of gliclazide therapy o | 50305
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International Research Journal of Pharmacy and Pharmacology

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Pharmacodynamics model of the effect of gliclazide therapy on Hemoglobin A1C in response in patients with type 2 diabetes


Abdel Qader Al Bawab

Diabetes is a global health issue that affects more than 425 million people and is expected to affect over 690 million people by 2045. Because of its large propagation and related economic costs, diabetes is considered a main public health concern nationally and worldwide. Gliclazide (GLC) is a very commonly used oral hypoglycemic agent that is used in treatment of type 2 diabetes. As per the clinical treatment guidelines; GLC is considered as a second line treatment that is typically used concomitantly with metformin. Predictors to clinical outcome of using GLC (with metformin as a background therapy) is lacking. This study sheds the light of various predictors that are correlated to the effect of GLC on glycated hemoglobin (HbA1c) and facting plasma glucose (FPG).

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