Palindromic nucleotide substitutions: A new software for pes | 17232
International Research Journals

International Research Journal of Biochemistry and Bioinformatics

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Palindromic nucleotide substitutions: A new software for pestivirus genotyping


Massimo Giangaspero, Claudio Apicella, Ryô Harasawa

The genus Pestivirus of the family Flaviviridae is represented by four established species; Bovine viral diarrhea virus 1 (BVDV-1), Bovine viral diarrhea virus 2 (BVDV-2), Border disease virus (BDV) and Classical swine fever virus (CSFV) and a tentative �?¢�?�?��?�?Giraffe�?¢�?�?��? species. The palindromic nucleotide substitutions (PNS) in the 5�?¢�?�?��?�?� untranslated region (UTR) of Pestivirus RNA have been described as a new, simple and practical method for genotyping. The preparation of specific software was considered for an easy access of the users to the method. In the present study, the new software, named PNS, was prepared and the application on the genotyping procedures with the keys for Pestivirus identification as specific PNS at genus, species and genotype level, respectively, was evaluated on five hundred-tirty-four sequences. The software is freely available at

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