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NIV in COPD and OHS patients: Predictors of short and long term survival| Abstract

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NIV in COPD and OHS patients: Predictors of short and long term survival

Abstract

Karadontas I, Tsolaki V, Zikiri A, Dimoulis A, Pinaka M, Gourgoulianis KI, Pastaka Ch

Acute Exacerbations of Chronic Hypercapnic Respirat ory Failure (CHRF) are associated with increased mortality during hospitalization and after hospital discharge. The aim of the study was to estimate sho rt and long term survival in patients hospitalized for acute respiratory failure. 177 patients (100 Chroni c Obstructive Pulmonary Disease, COPD and 77 Obesity Hypoventilation Syndrome, OHS) hospitalized for acute respiratory failure and treated with Non Invasive Ventilation (NIV) were enrolled. 2 year survival was evaluated in all patients and predicto rs of survival not only during hospitalization but i n the period after, were explored. Survival during ho spitalization in the COPD group was 94%, while there were no deaths in the OHS group. Increased age (B 0 .132, p=0.02) and the level of hypercapnia (B - 0.159, p=0.018) were significant predictors of surv ival in COPD group. 2-year survival in both groups was affected by the use of NIV (p<0.001 for both gr oups), while in COPD group sex (B -1.248, p=0.036) and FEV 1 /FVC (B 0.096, p=0.005) were additional predictors. Patients presenting with acute respiratory failure due to COPD or OHS, can be effectively trea ted in a regular ward with NIV. Receiving NIV at home directly after hospital discharge can prolong survival.Word count 197.

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