Gram-negative pathogen Pseudomonas aeruginosa has emerged as a significant human infection that can be associated with significant morbidity and mortality. Immuno compromised patients or those with chronic, debilitating conditions typically suffer from severe infections. Its ability to adapt to a wide range of environments, virulence factors, and antibiotic resistance increase its significance as a pathogen. P. aeruginosa can exhibit multiple acquired or intrinsic resistance mechanisms, frequently exhibiting high rates of resistance to various antimicrobial classes. The so-called "high-risk clones" of P. aeruginosa that are multidrug-resistant or extensively drug-resistant have become a public health threat in recent years and require urgent and determined research and management. One of the most prevalent Gram-negative bacteria that causes nosocomial and healthcareassociated infections in hospitalized patients is P. aeruginosa. Hand hygiene (with the appropriate use of alcoholbased solutions), contact precautions, patient isolation (single room or cohort), environmental cleanliness, and surveillance should all be implemented in healthcare facilities to prevent the spread of multi resistant P. aeruginosa.
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