In vitro investigations on the potential roles of Thai medic | 16705
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International Research Journal of Pharmacy and Pharmacology

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In vitro investigations on the potential roles of Thai medicinal plants in treatment of cholangiocarcinoma


Tullayakorn Plengsuriyakarn, Vithoon Viyanant, Veerachai Eursitthichai, Arunporn Itharat and Kesara Na-Bangchang

The aim of the present study was to investigate the potential roles of the crude ethanolic extracts of rhizomes of Zingiber Officinale Roscoe (Ginger, ZO) and Atractylodes Lancea(Thung.) DC. (Khod-Kha-Mao, AL), fruits of Piper chaba Hunt. (Dee-Plee, PC), Pra-Sa-Prao-Yhai formulation (a mixture of parts of 18 Thai medicinal plants, PPF), and curcumin compound (CUR) for treatment of cholangiocarcinoma (CCA) in different in vitro models (cytotoxic, antioxidant, anticlonogenic activities, and inhibitory effects on cell invasion and angiogenesis). The cytotoxic activity of the test materials against the CCA cell line CL-6 (selectivity index: SI = 3.93-18.26) was found to be more specific when compared with HepG2 (SI = 2.17-6.35). All test materials were significantly more potent than the reference drug 5-FU in CL-6 for both cytotoxic assays. CUR compound produced the most potent antioxidant activity with potency of about 2-3 times of 5-FU. AL produced the most potent inhibitory effect on clonogenic survival of CL-6 cells compared with the reference drug 5-FU and control. The test materials at all concentration levels significantly inhibited tube formation and inhibitory effects on cell invasion. Altogether, results suggest the potential roles of some Thai medicinal plants in treatment of CCA.

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