International Research Journal of Biochemistry and Bioinformatics

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In vitro antifungal effects of aqueous garlic extract alone and in combination with azoles against dermatophytic fungi.

Abstract

Farzad Aala, Umi Kalsom Yusuf, Sassan Rezaie, Behroz Davari and Farnaz Aala

Dermatophytes are fungi able to invade keratinized tissues, causing dermatomycosis. Azole antifungal drugs are used in the treatment of dermatomycosis, but have side effects and resistance may develop against them. In this study, garlic, which is a medicinal plant with antifungal activity, was tested. The study evaluated the in vitro efficacy of garlic extract alone against 10 isolates of Trichophyton rubrum and it was found that the MICs ranged from 0.0156-0.5 mg/ml, whereas the MIC values for 6 other dermatophyte isolates ranged from 0.0156-1.0 mg/ml. In conclusion, when used alone, aqueous garlic extract showed very good potential as an antifungal compound, and in combination of garlic extract with ketoconazole or fluconazole showed synergistic or additive interaction against dermatophytes.

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