Factors affecting Antimicrobial Sensitivity in Positive Stap | 17631
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International Research Journal of Microbiology

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Factors affecting Antimicrobial Sensitivity in Positive Staphylococcus aureus clinical isolates from Assir region, Saudi Arabia


Nazar M Abdalla*, Waleed O Haimour, Amani A Osman, Mohammed N Mohammed, Hassan A Musa

This study aimed to assess factors affecting antimicrobial sensitivity in Staphylococcus aureus clinical isolates from Asser region, Saudi Arabia. 81 patients presented with Staphylococcus aureus infections were involved by collecting nasal swabs at Asser Central Hospital General Laboratory. All age groups and both sex were involved, during the period of Jun 2011- Jan 2012. Laboratory tests performed including; microscopy and culture, antibiotics sensitivity test; minimum inhibitory concentration (MIC) and polymerase chain reactions (PCR) for detection of Mec A gene. Data were collected and analyzed by statistical computer program (SPSS). 50 patients were Staphylococcus aureus MecA gene positive that showed: variable resistance to Ciprofloxacin and Fusidin in diabetic and non diabetic patients and 100% resistance to Oxacillin/ Mithicillin. In Staphylococcus aureus MecA gene negative (31 cases) showed: variable resistance pattern to Ciprofloxacin and Fusidin and 100% sensitive to Oxacillin/ Mithicillin. Erythromycin in Staphylococcus aureus (MecA gene) positive cases (50) showed: 10% resistant in age (0-15 years), 32% in age group (16-50 years) and 24% in ( ›50 years). Erythromycin in Staphylococcus aureus (MecA gene) negative cases (31) showed:19.3%, 16.1% and 3.9% in age groups respectively. Drugs resistance is a major progressive multi factorial problem facing the treatment of Staphylococcus aureus infections.

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