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Existence of endogenous ligand from secretory granules of bo | 16758
International Research Journals

Existence of endogenous ligand from secretory granules of bovine adrenal medulla for neurite outgrowth in PC12 cells.

Abstract

Prabhu S.M, Abbas mohaoden

Memory function is sensitive to the effects of aging, and memory loss is one of the most common complaints among the elderly population.. Proliferation and differentiation of cells in response to extracellular signals is influenced by the differential regulation of MAPKs. The PC12 cells are wildly used as a cell system for the study of growth factor��?stimulated cell functions, in which the intensity and duration of activation the ERK have been proposed to govern a distinct switch between cell proliferation and differentiation. In the present study we have purified a protein ligand from secretory granules of bovine adrenal medulla which significantly activates the phosphorylation of serine/threonine protein kinase (Akt) and Extracellular signal-Regulated protein Kinase (ERK) and stimulation of neurite outgrowth in vitro.

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