A.A. Bakare
The aim of this study was to determine the effects of immature coconut water on metoclopramide-induce oxidative stress in female Sprague-Dawley rats Materials and Methods: The experiment was divided into 6 experimental study groups (I- VI). In experiment I, 5 rats received metoclopramide at 0.2mg/100g body weight/day and withdrawn for 8, 16 and 28days after induction. Experiment II, post-treated with 5ml/100gbw and 10ml/100gbw of immature coconut water. Experiment III rats were co-administered with 0.2mg/100g body weight of metoclopramide and 5ml and 10ml/100gbw of immature coconut water. In experimental group IV, the rats were pre-treated with 5ml and 10ml/100gbw of immature coconut water. Experiment V of 5 rats received immature coconut water only and Experiment VI, the control group received distilled water only. Results: There were statistical significant decrease in the concentration of MDA and increase in the concentrations of SOD, CAT and GSH when compared with the control. Conclusion: Green coconut water posses antioxidant properties in hyperprolactine rats.
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