S.E. Oriaifo and E. K. I. Omogbai
The objective of the study was to determine the effect of sertraline on the antidepressant-like responses of furosemide and bumetanide in the forced swim test (FST) and tail suspension test (TST) in mice. Groups of mice were treated for 30 days with placebo, furosemide (10mg/kg) + sertraline (5mg/kg), bumetanide (2.5mg/kg) + sertraline (5mg/kg) respectively. Experiments were done on Days 1, 15 and 31 in the FST and TST to determine the effects of the agents on duration of immobility. In the FST, results showed that in the test groups, furosemide and bumetanide potentiated the prolongation of the period of onset of immobility of sertraline significantly when acute values were compared to control values (F(2, 15) = 6.82, P < 0.05, < 0.01), when subchronic values were compared to acute values (F(2, 15) = 9.67, P < 0.05, < 0.01) and when chronic values were compared to subchronic value (F(2, 15) = 13.89; P < 0.05, < 0.01). These results were comparable to the experimental results obtained in the TST. In conclusion, results show that subchronic and chronic furosemide administration significantly potentiated the reduction of immobility in the FST and TST of chronically-administered sertraline more than bumetanide administration.
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