Muhammad Khurram Waqas
Botanical photochemoprotectives are used because they act on various stages to prevent skin cancer and photoaging. The aim of this study was to prepare Emulsions from various photochemoprotective herbs and to perform efficacy studies on them by using physicochemical, microbiological, safety, psychometric, biophysical, and sun protection factor measurements.Emulsions were prepared by incorporating hydroalcoholic extracts of grapes (seeds), Glycin max (Soybean seeds) and Tamarindus indica (fruit pulp) in varied concentrations (1–5% w/w) in a base cream. The efficacy of all formulations was checked out for four weeks on 60 normal subjects on the volar forearm for evaluation of biophysical properties, and for psychometric evaluations (fragrance, lathery feel, softness, irritation, stickiness, smoothness, and aftereffect on the skin) and safety measurements. In the biophysical characterization, a cutometer for viscoelasticity, a mexameter for melanin content, a corneometer for hydration, and a sebumeter for sebum determination were used. All the cream formulations with 1% and 3% w/w extracts showed positive results and passed physicochemical, microbiological, and safety tests. The SPF values increased as the concentration of extract was increased up to a limit in the formulations. The SPF values were significantly higher (p < 0.01) in formulations with 3% herbal extract than with 1% herbal extract. Increased skin hydration, sebum levels, viscoelasticity, and decreased melanin values were obtained. Tamarindus formulations were found more effective as photoprotectives than the grape seeds and Soybean formulations.
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