Comparison of the antiglycemic and hypolipidaemic effects of n-hexane and methanol leaf extracts of Nauclea latifolia in alloxan-induced diabetic rats

Abstract

Effiong G.S

Diabetes Mellitus has been known to be associated with lipid disorders and cardiovascular complications. The aim of this study was to evaluate and compare the hypoglycemic and hypolipidaemic effects of n-hexane and methanol leaf fractions of Nauclea latifolia in diabetic rats. The induced diabetic rats were administered 150mg/kg and 300mg/kg body weight respectively of the two fractions of Nauclea latifolia or 5mg/kg body weight of glibenclamide for fourteen days. Fasting blood glucose levels were measured and the lipid profile was analyzed. There were significant reductions (p<0.05) in the fasting blood glucose levels in all the groups treated with the leaf fractions when compared with the diabetic control. There were also significant (p<0.05) decreases on the lipid profile as shown in the level of total cholesterol and low density lipoprotein cholesterol. Results of this study show that leaf fractions of Nauclea latifolia possessed antidiabetic properties with the methanol fraction exerting a more potent effect.

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