Haemonchus contortus, the causative agent of haemonchosis, is an economically important parasite in ruminant populations. The parasite has a strong ability towards drug resistance, so chemotherapy is not effective for its control. There has been a continuous exploration for alternative ways of its treatment particularly from plant sources. The present study intended to evaluate the antihelminthic activity of crude methanolic and hexane extracts of Abutilon theophrasti fruitbody against H. contortus. The extraction was done by simple maceration. Methanol and hexane extracts were used for the analysis. The egg hatch test and larval motility test were employed to evaluate the potential of the extract against H. contortus. Concentrations of 500, 250, 125, and 62.5 mg/ml were made. Levamisole and distilled water served as control, respectively. Anthelmintic activity was initially tested on Pheretima posthuma due to its morphological resemblance with other gastro-intestinal nematodes. All selected extracts displayed concentration-dependent inhibition. At higher concentration (500 mg/ml), methanol and hexane extracts showed 90.68% and 80.65% inhibition in EHT, respectively. Meanwhile, inhibition of larval motility was higher with inhibition percentage of 82.8% and 75.58% by methanolic and hexane extracts, respectively. The present study concludes that methanolic extracts were more potent than hexane extracts in all assays. The study also showed that inhibitory effect of A. theophrasti was concentration dependent. The current research evidenced the anthelmintic potential of the fruitbody of A. theophrasti as natural medicine against this parasite for the savior of livestock.
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