Gautam Piplai, 1Indrani Chakrabarty DA, Madhumita Mukhopadhyay, MS, Manas Karmakar, Sabyasachi Sarkar MS, and Dhurjoti Prosad Bhattacharjee
Post operative nausea and vomiting (PONV) is common after laparoscopic surgery. Vomiting may create problems like electrolyte imbalance, dehydration and increased perception of pain. A number of pharmacological approaches (butyrophenones, antihistaminics, and dopamine receptor antagonists) have been tried for the prevention and treatment of PONV but undesirable adverse effects such as dryness of mouth, excessive sedation, hypertension, dysphoria, hallucinations and extra pyramidal symptoms have been noted. 5- hydroxytryptamine type3 (5HT3) receptor antagonists are not only devoid of such side effects but also highly effective in prevention and treatment of PONV. Ramosetron is a highly selective and potent 5-HT3 receptor antagonist. It is more potent and longer acting than previously developed 5-HT3 receptor antagonists at equivalent doses. It is more effective than granisetron against cisplatin-induced emesis.
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