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International Research Journals

International Research Journal of Biochemistry and Bioinformatics

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Zuzana Brnoliakova

Center of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovak republic

Publications

  • Short Communication   

    Author(s): Zuzana Brnoliakova*

    Statement of the Problem: Glycosylation is one of the most common posttranslational modifications of proteins. Altered glycosylation is present in many pathophysiological conditions. Glycomic studies on rat serum have revealed variations in the N-glycans of glycoproteins correlated with disease progress, which is consistent with the findings in human serum. The main goal of our study was to describe the glycoprofiles of different rat strains fed 5 weeks standard diet and to evaluate their differences according to the N-glycan type. Methodology & Theoretical Orientation: For our observation we used Wistar rats (W), the general multipurpose model strain. Then spontaneously hypertensive rats (SHR) were used, developed as animal models for human essential (idiopathic or primary) hypertensions. Finally, hereditary hypertriglyceridemic rats (hHTG) were also included, regarded a.. View More»

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