Review
X-chromosome inactivation
Author(s): Nicklaus Jamie*
One of the two X chromosomes in female cells randomly becomes inactive throughout development. When the Xist genes transcribed RNA covers the whole X chromosome on the X chromosome from which it is produced, inactivation takes place. Nesterova and colleagues examine the function of the RNA interference pathway enzyme Dicer in the DNA methylation of the Xist promoter in the inaugural issue of Epigenetics and Chromatin. In order to equalise the dosage of X chromosome gene products between XX females and XY men, one X chromosome must be transcriptionally silenced in female mammalian cells. Early in development, the X chromosome becomes inactive in the embryo (Edem et al., 2012). Equal chances exist for both X chromosomes to be silenced. Once established, silencing is enduring because the identical X chromosome stays inactive in all succeeding cell generations. As a result, each female is.. View More»
DOI:
10.14303/2250-9941.2023.58