T. T. Adeniyi, G.O. Ajayi, M. A. Sado and H. J. Olopade
The ameliorative effects of vitamin C and garlic ( Allium sativum ) on nephrotoxicity and biochemical alterations induced in lead-exposed rats were inves tigated. Results showed significant (p < 0.05) reduction in the levels of glucose (GLC), total pr otein (TPR), albumin (ALB), cholesterol (CHL), haemoglobi (Hb), and packed cell volume (PCV) and s ignificant (p < 0.05) elevation in plasma levels of lead (Pb), uric acid, creatinine and concentration of erythrocyte protoporphyrin (ERY) in lead nephrotoxic rats. However, post-treatment with garl ic and vitamin C significantly (p < 0.05) ameliorat ed elevations in the plasma levels of Pb, uric acid, c reatinine and ERY. Garlic and vitamin C also significantly (p < 0.05) improved GLC, ALB, CHL, Hb , and PCV. Therefore, the overall results showed that garlic ( Allium sativum ) and vitamin C ameliorate biochemical alterations and further protect against lead-induced nephrotoxicity in rats with vitamin C showing more effectiveness on most parameters.
Share this article