GÃÆÃÂ¼rsoy G, AkÃÆÃÂ§ayÃÆÃÂ¶z Ãâ¦ÃÅ¾S, Acar Y, DemirbaÃâ¦ÃÅ¸ B
Hyperlipidemia was a modifiable major risk factor in primary and secondary prevention of cardiovascular diseases. In recent studies it was demonstrated that adipose tissue besides being a store of lipids, was a site that secrete bioactive proteins into the circulation, one of which was visfatin. In clinical trials visfatin levels were found to be related to lipid parameters and obesity. In our study, we intended to show the relation of visfatin with lipid profile and metabolic parameters. The study included 60 female patients and 20 age matched control subjects. As well as making physical and antropometric examinations, fasting plasma glucose and insulin, post prandal plasma glucose and insulin, lipid profile, uric acid, homocysteine, c-reactive protein and visfatin levels were measured in all female subjects. Hyperlipidemic group had significantly higher plasma visfatin levels than control group ( p < 0.01). In hyperlipidemic patients positive correlation was found between triglyceride and visfatin levels and negative correlation between low density cholesterol and visfatin levels. Then we classified our patient group with an indirect measure of insulin resistance as homeostasis model assesment 2.7 and homeostasis model assesment < 2.7. We found that the group with homeostasis model assesment 2.7 had significantly high triglyceride, postprandial glucose, post prandial insulin and visfatin levels ( p < 0.05). In conclusion, our data may point toward a role of visfatin in lipid parameters and insulin resistance.
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