Fatou Cisse*, Tarik Lamkinsi, Souleymane Thiam, Arame Ndiaye, Abdourahmane Samba, Idrissa Yayah Soumah, Fatou Diedhiou, Fatou Diallo and Alassane Diatta
Background and purpose: Hormones of the hypothalamic-pituitary-gonadal axis are important markers for the evaluation of several pediatric endocrinopathies. However, in Senegal, the reference values used by prescribers and biologists so far are those of Western countries.
Materials and methods: The study is of the prospective type over a period of 6 months carried out at the level of the biochemistry laboratory of the Dalal Jamm hospital in collaboration with the laboratories of the Abass Ndao hospital and the biochemistry laboratory of the hospital. Aristide Le dantec. Our study population consisted of 101 patients from the pediatric population and the dosage of gonadotropins was carried out by the electrochemiluminescence method. Usual gonadotropin values and their confidence intervals were calculated.
Results: Our study population consisted of 51% girls and 49% boys with an M/F sex ratio of 0.96. We divided our population into four distinct intervals and we found that the age group between 2 years and 10 years is the most represented with a percentage of 58%. For FSH we found a usual value between 0.1 and 4.685 IU/L with a median of 0.507. While for LH, we found a value between 0.1 and 3.275 IU/L and a median of 0.1. We also found that FSH and LH do not have the same gender distribution. Indeed FSH is higher in girls while LH is higher in boys.
Conclusion: Our study provided the first results in Senegalese children and the results that came from it could serve as a reference for laboratories that use the same platform. However, further studies on a larger population are necessary to confirm these data. We recommend that each laboratory establish the reference values or, failing that, the usual values according to its population but also according to the methods used.
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