Onyenwe, N.E*., Adeleke, O.E, Mbata, T.I., Udeji,G.N.
Staphylococcus aureus strains from bovine and human clinical sources were investigated. The level of Beta-lactamase mediating antibiotic resistance on them were determine on a comparative basis and the possible drugs of choice for treatment of this disease causing organism, especially those causing mastitis in cow. All the strains were penicillin resistant including the control strains (NCIB8588 and ATCC25923). A total of 20 (80%) of the bovine strains and 17 (68%) of the human were Beta-lactamase producers. The bovine strains recorded high resistance to augmentine 18(72%), erythromycin 22(88%), amoxycillin 22(88%) and cloxacillin 24(96%) when compared to the human strains. All the Betalactamase producing strains were sensitive to all cephalosporin class of drugs screened on them. The coefficient of variations from the differences of the means in the individual treatment effect of Betalactam drugs used and strain differences at p>0.05 was observed to be 40.79% and 36.89%,with a standard error deviation of ±1.15mm and ±1.29mm for the bovine and human strains respectively. These reveal no relationship between the level or type of Beta-lactamase produced by the bovine and human strains of S.aureus with respect to the mode of resistance and rate of the enzyme produced.
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