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Sub acute toxicity studies of the herbal cough mixture (hamekof) in adult male wister rats| Abstract

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Sub acute toxicity studies of the herbal cough mixture (hamekof) in adult male wister rats

Abstract

Otimenyin SO, Olorunfemi PO., Sabo YS and Attah SH

Sub-acute toxicity study was designed to investigat e and ascertain the safety profile of the herbal cough mixture (Hamekof) in adult male wister rats. In this study, Hamekof was administered orally based on the body weight of the rats for a period o f 28 days while the control group received 2 mls of distilled water for the same period. There were no changes in behaviors and physiological activities. Blood chemistry analysis showed no significant chan ges in the plasma concentration of albumin, cholesterol, triglyceride, creatinine, Total protei n, potassium, alanine transaminase, (ALT), alkaline phosphatase, (ALP). Hamekof altered blood levels of aspartate transaminase, (AST), calcium, urea and sodium plasma concentration. Haematological analysi s showed no significant changes in blood parameters (WBC count, RBC count, PCV, hemoglobin ( Hb) concentration, platelet and differential count) except for clotting time, which was signific antly reduced. There were no significant difference in the body and organ weights between control and trea ted animals. Gross and histopathological examination revealed normal cells, with no abnormal ities nor histopathological changes.

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