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Serum alanine aminotransferase (ALT) and aldosterone levels correlate with the severity of liver fibrosis in chronic viral hepatitis C| Abstract

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Serum alanine aminotransferase (ALT) and aldosterone levels correlate with the severity of liver fibrosis in chronic viral hepatitis C

Abstract

Abu Hassan, Kassim RMN, Mustapha NRN, Ooi BP, Pani SP, Thambirajah JJ, Kyaw Min

In patients suffering fromchronic hepat itis C (CHC), liver biopsy is performed to assess the severity of liver fibrosis. However, liver biop sy essentially is an invasive technique fraught wit h complications and its accuracy is also debatable du e to sampling errors and subjective bias in the interpretation of the findings. Aim: To determine t he correlation between the index of fibrosis inchronic hepatitis C and the serum level of variou s markers of liver damage and dysfunction. The serum markers analyzed were of two types (i) liver e nzymes; alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT); (ii) Serum markers of liver biosynthetic function: -albumin, prothrombin time (PT), high density lipoprotein (HDL), low density lipoprotein (LDL), haptoglobin and aldoster one.

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