Akinrinade I. D., Ogundele O. M., Memudu A. E., and Caxton-Martins E. A.
Some of the effects of Therapeutic, Acute, and Over dose treatment of Chloroquine, Artesunate, and Amodiaquine- Artesunate combined therapy on the Lef t ventricle and Ascending Aorta of Adult wistar rats were studied using biochemical estimation of a ctivities of Lactate dehydrogenase and Glucose 6 phosphate dehydrogenase. The drugs were dissolved i n distilled water and administered orally using an orogastric tube. The animals were sacrificed on days 1, 3, and 5 respectively after which the excis ed tissues were subjected to biochemical analysis. The levels of Lactate dehydrogenase and Glucose 6 phosphate dehydrogenase in the Left ventricle and A scending aorta was highest in the Overdose treatment groups showing statistically significant results (P< 0.05) following treatment with Chloroquine, Artesunate, and Amodiaquine- Artesunat e combined therapy. There was also statistically significant alteration (P< 0.05) in their activitie s in the Left ventricle and ascending aorta, of the animals treated at Acute dose of the drugs. However, there was no statistically significant alteration (P< 0.0 5) in the levels of Lactate dehydrogenase and Glucose 6 p hosphate dehydrogenase in the Left ventricle and ascending aorta of the animals treated with the The rapeutic dose of the drugs. The findings in this study suggests that Chloroquine, Artesunate and Amo diaquine – Artesunate combined therapy altered the enzymatic antioxidant defense system and elevate d the levels of Lactate Dehydrogenase in the Left ventricle and Ascending Aorta of the Adult wistar r ats.
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