Breast cancer is the most frequently occurring cancer in women with one in eight women in the United States expected to be diagnosed with breast cancer during their life. This high rate of incidence makes breast cancer the leading cause of mortality from cancer in women. Treatments for most patients include a combination of surgery, chemotherapy, hormone therapy, ionizing radiation or administration of biologicals (e.g. herceptin). However, these treatments often fail and a significant number of women are faced with the prospect of metastatic disease. Despite significant improvements in the treatment of metastatic breast cancer, the 5-year survival rate is still less than 50%. Chemotherapy is the most common approved therapy for metastatic breast cancer but it frequently fails to provide long-term control of breast cancer. Innovative therapies are needed to successfully treat primary breast tumors and prevent breast tumor metastases. We hypothesize that Pseudomonas aeruginosa Exotoxin T possesses unique properties that make it an ideal candidate to be used alone or in combination therapy to eradicate and prevent breast cancer metastases. These properties include: (1) its potent cytotoxicity against highly resistant and metastatic cacer cells; (2) its ability to prevent Apoptotic Compensatory Proliferation Signaling; (3) its anti-proliferative impact on various tumor cells; (4) its ability to inhibit tumor cell migration; and (5) its potential to induce durable and systemic anti-tumor immunity.
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