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International Research Journal of Microbiology

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Prevalence of multi-drug resistance and pandrug resistance among multiple gram-negative species: experience in one teaching hospital, Tehran, Iran

Abstract

Zohreh Aminizadeh* and Mohtaram Sadat Kashi

Resistance in specific gram-negative bacteria, including Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa is of great concern, for there are growing numbers of reports of how these microorganisms have become resistant to all available antibacterial agents used in therapy. A descriptive study was conducted in a teaching hospital in Tehran, Iran, in 2008. A Total of 295 clinical gram negative species were isolated at Microbiology Laboratory Hospital from patients’ specimens. Anti-biograms were done on Mueller-Hinton agar plates with disk diffusion method according to Kirby-Bauer method. Among 295 isolated gram-negative, Escherichia coli was the most common organism then followed by K. pneumoniae, Enterobacter, P. aeruginosa, Acinetobacter, Proteus and Citrobacter. Multi-drug-resistant (MDR) gram negative strains were detected in 162(55%) of isolates. These included E. coli [67(41.35%)], K. pneumoniae [35(21.6%)], P. aeruginosa [27(16.7%)], Enterobacter [19(11.73%)], Acinetobacter [14(8.65%)]. Ten patients were identified to have infection due to pandrug-resistant (PDR) gram-negative bacteria including: P. aeruginosa [3 cases (30%)], A. baumannii [3 cases (30%)], Enterobacter [2 cases (20%)], K. pneumoniae [1 case (10%)], E. coli [1 case (10%)]. Presence of MDR and PDR resistance and reduced susceptibility to third generation cephalosporins, carbapenems and fluoroquinolones, aminoglycosides, and Trimethoprim-sulfamethoxazole is considered a serious clinical problem.

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