Koffi Kouakou Jacques, Doumbia Idrissa1, MÃÆéitÃÆé Souleymane, Yapi Houphouet FÃÆélix, Djaman Allico Joseph, NâÃâ¬Ãâ¢guessan Jean David
This study aimed to evaluate anti-hyperglycemic activity of aqueous and 70% ethanol extracts of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae) in normoglycemic rabbits by oral glucose tolerance test. Blood samples were collected from the marginal vein (0 h) and then drugs (extracts and glibenclamide) were administered to each group of rabbit by oral route. One hour (1 h) later, glucose (4 g/kg, p.o.) was administered in all groups. Blood samples were collected at 1 h, 2 h, 4 h and 6 h after administration of drugs. Blood was centrifugated at 3500 rpm during 5 min and the serum was analyzed to determine glucose, triglycerides and cholesterols levels. Aqueous and ethanol extracts (500 and 800 mg/kg) of M. morindoides had no effect on basal glycemia. Both extracts of M. morindoides significantly lowered the subsequent hyperglycaemia induced with glucose (10 mg/kg) administered per os. Moreover, the pretreatment of normal rabbits with M. morindoides aqueous and ethanol extracts normalized faster the glucose levels (3 h after glucose administration) compared to the hyperglycemic control group (5 h after glucose administration). M. morindoides have a considerable antihyperglycemic activity which justifies the use of this plant in traditional herbal medicine practice for the treatment of diabetes mellitus.
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