W. Shukun, C.Congjia, Y. Yunbo, K. Biao, and D. Baowei
Antimicrobial susceptibility tests were performed w ith 4060 strains of Salmonella enterica serotype Paratyphi A (SPA) isolated from patients at Yuxi Ci ty from 1999 to 2008. The incidence of resistance t o nalidixic acid of the isolates increased from 12.5% in 1999 to 82.2% in 2000, 93.0% in 2001, and 100% in 2008. The frequencies of intermediary and susceptib ility (Kirby-Bauer disc diffusion technique) to ciprofloxacin were 17.0% and 83.0% before 2005, 65. 3% and 34.7% in 2008, respectively. A group of 166 NAR and 20 NAS isolates of SPA were typed by pulsed -field gel electrophoresis (PFGE) using SpeI into nine different PFGE patterns with predominance of t he SpeI01 and SpeI02. All NAR isolates had higher MICs for fluoroquinolone. We validate the use of th e nalidixic acid screening test for detection of decreased fluoroquinolone susceptibility in SPA.
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