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Newborn danger signs are a major challenge to negotiate successfully from intra-uterine to extra-uterine life of the new-born. Danger signs in the neonatal period (0-28 days) are nonspecific and can be a manifestation of almost any newborn disease. The Aim of this study was to assess the level of knowledge on neonatal danger signs and associated factors among mothers who give birth. Facility based cross sectional study was conducted and data was collected by using structured pre-tested questionnaire. A total of 182 mothers were participated. The data was analyzed by using SPSS version 21and P-value less than or equal to 0.05 was considered as statistically significant value. From all 182 mothers, only 87 (47.8%) of respondents were knowledgeable about Newborn danger sign. The most common source of information for interviewed mothers was health professionals (92%). The most common danger sign recognized by mothers were persistent vomiting 136 (74.7%), Lethargy/unconsciousness 134 (73.6%) and Poor sucking/Unable to feed 127 (69.8%). The odds of diploma/degree holders postnatal mothers were 57.75 times knowledgeable than as compared with those who were not literate. In general the knowledge of the mothers on neonatal danger sign was good. Majority of health professionals had commitment to provide information for mothers about neonatal dangers signs
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