Increase activity of serum total and prostatic acid phosphat | 18230
International Research Journals

Increase activity of serum total and prostatic acid phosphatase, alkaline phosphatase, gamma glutamyltransferase and testosterone level in rats exposed to gasoline vapours


F. E. Uboh, M. I. Akpanabiatu, E. E. Edet and P. E. Ebong

In this study, changes in the activities of serum total and prostatic acid phosphatase (TACP and PACP, respectively), alkaline phosphatase (ALP), gamma()-glutamyltransferase (GGT) and testosterone level were assessed in male rats exposed wholly to 17.8±2.6cm 3 hr -1 kg -1m -3 day -1 of gasoline vapours (8 hours daily, 6 days/week) for 20 weeks in exposure chambers. The results showed that exposure to gasoline vapours caused a significant increase (P < 0.05) in serum TACP, PACP, ALP, GGT and testosterone levels, by 74.12 ± 4.71, 74.00 ± 2.80, 53.00 ± 3.6, 87.17 ± 2.5 and 83.42 ± 5.2 percents, respectively, in male rats. Increase in serum acid and alkaline phosphatases,  - glutamyltransferase and testosterone levels, observed in this study to be associated with exposure of male rats to gasoline vapours, is known to be implicated in various prostatic clinical conditions, including prostatic cancer.

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