The study was aimed to explore the phytochemicals present in the ethanol and acetone extracts of Oldenlandia corymbosa by GC-MS analysis and to determine the neuroprotective and antioxidant potential of both of the extracts. The GC-MS analysis of the ethanol and acetone indicated the presence of carotenoids, polyphenols, diterpenes, and fatty acids. Neuroprotective effect of ethanolic (OCWE) and acetone extract of Oldenlandia Corymbosa (OCWA) on IMR-32 Neuroblastoma cell lines were evaluated by MTT assay and the results showed that ethanol extract of the plant got more neuroprotective activity on cell lines. The antioxidant results showed that both of the extracts had almost similar DPPH and ABTS radical scavenging. However, the ethanol extract had more potent antioxidant power than the acetone extract. Study data suggest that whole plant of Oldenlandia corymbosa possesses neuroprotective and anti-oxidative activities and the best neuroprotective and anti-oxidant activity being exhibited by the ethanolic extract of the plant.
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