Evaluation of hypoglycemic and hypolipidemic effect of chlo | 16648
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International Research Journal of Plant Science

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Evaluation of hypoglycemic and hypolipidemic effect of chloroform and methanolic extract of Nauclea latifolia (rubiaceae) on alloxan-induced diabetic rats


Effiong, G. S. and Essien, G. E

The abnormal lipid profiles and lipoprotein oxidation especially, Low density lipoprotein cholesterol is more common in diabetics and is aggravated with poor glycaemia control. In this study, hypoglycemic and hypolipidemic properties of chloroform and methanolic fractions of Nauclea latifolia leaves were investigated. 150mg/kg and 300mg/kg chloroform and methanol fractions were administered to alloxan- induced diabetic rats twice daily for a period of fourteen days. Their blood glucose level was measured every three days while Lipid profile was assayed at the end of the experiment. The two fractions significantly reduced (p<0.05) the fasting blood glucose levels compared to the diabetic control except in the 300mg/kg methanol fractions. Total Cholesterol and Low Density Lipoprotein Cholesterol were both reduced significantly (p<0.05) by the two fractions of Nauclea latifolia dose-dependently. Total Cholesterol reduced thus: Chloroform (150mg/kg=77.50±10.15mg/dl, 300mg/kg=82.72±16.21mg/dl) and methanol (150mg/kg=116.86±13.34 mg/dl and 300mg/kg=108.66±12.77 mg/dl) when compared to the diabetic control (383.76 ±79.68 mg/dl). Low density lipoprotein cholesterol: chloroform; (150mg/kg=8.77±8.02 mg/dl, 300mg/kg=27.93±11.38 mg/dl) and methanol (150mg/kg=50.688±14.13mg/dl, 300mg/kg=42.09±79.23mg/dl) when compared to the diabetic control (299.46±79.23mg/dl). Chloroform fraction shows more reductions of the two parameters. Thus suggesting a more hypoglycemic as well as favorable lipidemic potentials /effects on type 2diabetes.

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