Effects of alliums sativum extract on paracetamol induced he | 17026
International Research Journals

International Research Journal of Biochemistry and Bioinformatics

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Effects of alliums sativum extract on paracetamol induced hepatotoxicity in albino rats


L. N. Ebenyi, U. A. Ibiam and P. M. Aja

In the present study, an attempt has been made to evaluate the presence of antioxidant property and hepatoprotective activity in ethanol extract of Allium sativum on paracetamol- induced hepatotoxicity in albino rats. A total of 28 rats were used for the study. The rats were grouped into four with four rats in each group. Group A was the control, group B received paracetamol over dose (500mg / kg / ml) without extracts, and group C received paracetamol over dose plus extract of A.sativum at three different concentrations of 200, 400 and 800 ug / body weight. Oral administration of Allium sativum extract significantly decreased the level of liver enzymes (ALT, AST and ALP), Total protein and bilirubin to near normal levels. The increased levels of lipid peroxidation in tissues were reverted significantly. The treatment also resulted in a significant increased in GSH, SOD and Catalase in the liver. These results clearly show the antioxidant and hepatoprotective property of Allium sativum extract.

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