Effects of acute oral administration of sodium fluoride on t | 17949
International Research Journals

Effects of acute oral administration of sodium fluoride on the activities of sialidase and brain of adult mice


Wilson JI., Nok AJ., Hambolu JO., Esievo KAN

The use of fluorine and its compounds is widespread and adverse effects have been documented. Fluoride compounds which are put in water (fluorida tion), toothpaste and supplement tablets cross the blood brain barrier are said to be mutagenic and de stroys brain cells. Aim: Determination of sialic ac id levels in the brain tissues, haemoglobin-free eryth rocytes and serum, activities of the enzyme substrat e 4-Methylumbelliferyl-Neu5Ac and the histological ch anges of the hippocampus of mice following acute oral administration of Sodium Fluoride. Forty eight mice were subdivided into eight groups of six with weights ranging between 20 and 34 grams. Daily oral dose of 0mg, 0.5mg, 1mg, 5mg, 10mg, 15mg, 20mg and 30mg/kg BW/day of fluoride was administered to the mice in groups I, II, III, IV, V, VI, VII and V III respectively for fourteen days. Blood samples and b rain tissues were collected for sialic acid analyse s and histological changes. The data obtained were su bjected to statistical analysis and showed statistically significant differences between the e xperimental groups (p < 0.05). The dose of 20mg/kg b wt./day of fluoride showed sparse distribution of pyramidal cells in the pyramidal cell layer of hippocampus. 20mg/ml of Sodium fluoride even in acu te use may be toxic to the brain.

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