Lalit Singh*, Maneesh Kumar Gupta, Renu Dixit and Manju Rani
Nowadays, hyperlipidaemia is one of the major problems prevailing among humans, indicating increased blood lipids content like LDL, HDL, VLDL, Cholesterol, and serum triglyceride. LDL (Low-Density Lipid) is one of the five major groups of lipoproteins, which transport all fat molecules around the body in extracellular fluid. LDL is not considered good for the body as it can cause atherosclerosis, if, oxidized in the wall of the artery. HDL (High- Density Lipid) is also a lipoprotein, which is considered as good fat as it transports fat from the body within the water around cells. Serum triglyceride is a type of fat in the blood. High triglyceride in the blood may be responsible for coronary artery disease especially in human females. Moreover, increased lipid content in human blood can raise the risk of many heart diseases, including heart attack. The pharmacological effects of many plants like Abelmoschus esculentus attribute to various constituents like mucilage, tannins, terpenoids, flavonoids, and glycosides, present in all plant parts. The report suggests that okra mucilage, okra pectin, and okra fibres combat with heart diseases as it binds to cholesterol and bile acids, which carry toxins and dump it in the liver (Gemede, 2015). The present study was carried out to find out the efficacy of Abelmoschus esculentus aqueous extract to reduce Serum Triglyceride, Serum Cholesterol, HDL Cholesterol, VLDL Cholesterol, CHOL/HDL Cholesterol Ratio in the Human blood. Initially, the blood samples were collected prior to the administration of plant extract. Further, blood samples were taken after the 7th day, 14th day, 21st day, and 28th day of administration of whole plant extract. The blood samples were centrifuged for separating blood serum from the blood. The blood serum of each sample was analysed for lipid profile by using a fully automatic access Robertic biochemistry Analyzer (Response-90) by Diasys Company of Germany. From the current study, it can be concluded that oral ingestion of the pod extract of A. esculentus has the potential to reduce lipid content in human blood, including serum triglyceride, serum cholesterol, HDL, VLDL, LDL, and CHOL/HDL Cholesterol ratio
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