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International Research Journal of Microbiology

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Effect of nitric oxide donors and antibiotic against typhoid



Typhoid fever is an important communicable disease in many developing countries. Salmonella, gram negative bacilli, and can survive during certain stages of host parasite interaction. Nitric oxide (NO) is a versatile molecule produced in a biological system; previous studies have suggested that exogenous administration of L-arginine results in increased NO production, indicating that endogenous substrate is insufficient for maxim NO production. Taking these facts in to consideration, it was thought pertinent to see the effect of oral administration of NO donors i.e. L-Arginine. In this study we have evaluated NO donor and low doses of ciprofloxacin in connection with oxidative stress generated in Swiss albino mice by Salmonella typhimurium.

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